Oprah Daily: 6 Key Changes to Make When Starting a GLP-1

In 2026, it feels like everyone is taking a GLP-1—or at least thinking about it. The weight-loss drugs, which include Wegovy (semaglutide) and Zepbound (tirzepatide), have become more accessible than ever thanks to recent price cuts, expanding Medicare and Medicaid access, and (more controversially) compounded options from online pharmacies and health startups. The result: One in eight American adults report currently taking a GLP-1.

But experts worry that the explosion of demand (and prescribers trying to meet said demand) might impact how well patients handle being on these medications, which can come with a fair share of unpleasant side effects, from nausea to vomiting to diarrhea.

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